Digestive Hormones

Submitted by Thiruvelan on Tue, 11/22/2011

Digestive hormones - Gastrin, Secretin, cholecystokinin, Gastric Inhibitory Peptide and Motilin; it helps and regulates the human digestive process.

  • Gastrin is secreted by stomach
  • The presence of food in the stomach stimulates secretion of the gastrin into the circulatory system.
  • Gastrin in-turn stimulates the secretion of gastric juice in the stomach.


  • Secretin is secret by duodenum cells.
  • Secretin secretion is stimulating by acid chyme (food from stomach).
  • Secretin stimulates the pancreas to secrete sodium bicarbonate, which neutralizes the acidic chyme.
  • Secretin also stimulates the liver to release bile.

CCK (cholecystokinin)

  • CCK is secreting by the small intestine (mainly duodenum & jejunum).
  • CCK secretion is stimulating by the food present in the small intestine.

It stimulates the gallbladder to release bile and the pancreas to produce pancreatic enzymes.

GIP (Gastric Inhibitory Peptide)

  • GIP is secreted by the duodenum
  • GIP secretion is stimulating by the food in the duodenum.
  • It counteracts the effects of gastrin that is it inhibits gastric glands. Furthermore, slow down stomach emptying if there is food in the duodenum.


Motilin is in the duodenum, increases the migrating myoelectric complex component of gastrointestinal motility, and stimulates the production of pepsin.

Additional hormones in the digestive process that regulate appetite:

  • Ghrelin is produce in the stomach and upper part of the intestine in the absence of food for digestive and stimulates appetite.
  • Peptide YY is synthesizing in the digestive tract in response to the food and inhibiting appetite.
  • Both of these above-said hormones are in coordination with the brain to help regulate the intake of food for energy.